Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| PL45291 | 105157 | Portugal | 2004 | HIV1 | G | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ 3TC+ NFV | 8 |
| 2 | D4T+ 3TC+ NFV | 56 |
| 3 | D4T+ TDF+ EFV | 82 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R | K219Q | K103N | P225H | V35I, V60I, V90I, A98S, K122E, D123S, I135L, I142V, K173I, Q174K, D177E, I178L, T200A, Q207K, R211S, V245Q, D250E, S251D, A272P, K275KQ, T286A, E291ED, V292I, I293V, E297A, D320E, D324E, I329V |
| >105157| codons 1-333 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEIQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSLNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRIKNPELVI YQYMDDLYVGSDLEIGQHRAKIEELRKHLLSWGFTTPDQKHQKEHPFLWMGYELHPDKWT VQPIQLPEKEDWTVNDIQKLVGKLNWASQIYPGIQVKQLCKLLRGAKALTDIVPLTAEAE LELAENREILKEPVHGVYYEPSKELIAEVQKQG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | L23I | I13V, K20I, E35G, M36I, R41K, H69K, T74S, V82I, L89M |
| >105157| codons 1-99 PQITLWQRPLVTVKIGGQLIEAILDTGADDTVLEGINLPGKWKPKMIGGIGGFIKVRQYD QILIEICGKKAIGSVLVGPTPINIIGRNMMTQIGCTLNF |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |