<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
PL45175 80399 Portugal 2003 HIV1 A Plasma None

Treatment History
Order Regimen Weeks
1 AZT 47
2 AZT+ DDI 335
3 D4T+ 3TC+ EFV 59

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    L10I, I13V, K14KR, G16E, K20R, E35D, M36I, R41K, R57K, L63S, H69K, K70R, L89M  
>80399| codons 1-99
PQITLWQRPIVTVRIEGQLREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYD
QISIEICGKRAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70KR, M184V, L210W, T215F K219E K103KN, Y181YC   V35T, T39A, V60I, V118I, K122E, D123S, I135K, E169D, K173A, Q174K, D177E, I178L, V179I, Q207A, R211DN, F214FL, L228H, V245R, T286A, E291D, I293V, P294T, V317A, K331N  
>80399| codons 1-334
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAELEKEGKISKIGPENPYNTPI
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL
DESFRKYTAFTIPSKNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRAKNPELII
CQYVDDLYVGSDLEIGQHRTKIEELRAHLWNWGLFTPDEKHQKEPPFHWMGYELHPDKWT
VQPIRLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDVVTLTEEAE
LELAENREILKEPVHGAYYDPSKDLIAEIQNQGQ

References
Author Title Citation
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005