<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
PL45041 80062 Portugal 2003 HIV1 G Plasma None

Treatment History
Order Regimen Weeks
1 AZT+ 3TC+ NFV 130

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41ML, M184V       V35T, K43R, V60I, A98S, K122E, D123N, I135L, K173R, Q174K, I195K, T200A, R211S, V245Q, E248T, D250E, A272P, V276VI, T286A, E291D, V292I, I293V, E297A, D320E, D324E, I329V, Q334R  
>80062| codons 1-334
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEREGKISKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL
DENFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRRKNPDIVI
YQYVDDLYVGSDLEKGQHRAKIEELRQHLLSWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPTKESWTVNDIQKLVGKLNWASQIYPGIKIKQLCKLLRGAKALTDIVPLTAEAE
LELAENREILKEPVHGVYYEPSKELIAEVQKQGR

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
L90M   I13V, K20I, E35D, M36I, R41K, H69K, V82I, L89M  
>80062| codons 1-99
PQITLWQRPLVTVKIGGQLIEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD
QILIEICGKKAIGTVLVGPTPINIIGRNMMTQIGCTLNF

References
Author Title Citation
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005