Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| PL44044 | 77623 | Portugal | 2003 | HIV1 | G | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T+ DDI+ RTV | 47 |
| 2 | D4T+ DDI+ IDV+ RTV | 4 |
| 3 | D4T+ DDI+ NFV | 52 |
| 4 | D4T+ DDI+ NFV+ 3TC+ ABC+ EFV | 1 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82VA | L10LI, I13V, K14R, K20I, E35D, M36I, R41K, L63LP, H69K, A71AV, T74S, L89I |
| >77623| codons 1-99 PQITLWQRPIVTVRIGGQLIEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFVKVRQYD QIPIEICGKKVIGSVLVGPTPANIIGRNILTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65KR | V75VA | V35T, V60I, A98S, D121H, K122E, K166R, K173I, Q174K, D177E, G196E, T200A, E204D, Q207K, R211S, V245Q, E248D, D250E, A272P, K277R, T286A, I293V, E297R, E298D, Q334L |
| >77623| codons 1-335 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPI FAIKRKDSTKWRKLADFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL HEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRIKNPEIVI YQYMDDLYVGSDLEIEQHRAKIEDLRKHLLSWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVVPLTRDAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLG |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |