<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
PL43156 75500 Portugal 2003 HIV1 G Plasma None

Treatment History
Order Regimen Weeks
1 AZT+ DDI 52
2 AZT+ DDI+ SQV 60
3 D4T+ 3TC+ NFV 221

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
L90M   I13V, K14R, I15IV, K20T, E35DN, M36I, R41K, I62IV, H69K, A71T, T74S, V82I, L89I  
>75500| codons 1-99
PQITLWQRPLVTVRVGGQLTEALLDTGADDTVLENINLPGKWKPKMIGGIGGFIKVRQYD
QVLIEICGKKTIGSVLVGPTPINIIGRNIMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, M184V, T215Y K219E     V35T, E40D, K43R, V60I, S68G, K104KR, D121DH, K122E, D123S, K173IM, Q174K, D177E, T200A, Q207K, R211ST, V245Q, E248D, D250E, A272P, K277R, T286A, E291D, V292I, I293V, E297A, D324E, I329V  
>75500| codons 1-333
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTDLEREGKISKIGPENPYNTPI
FAIKKKNGTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKRSVTVLDVGDAYFSVPL
HESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRMKNPEIVI
YQYVDDLYVGSDLEIGQHRAKIEELRKHLLTWGFYTPDEKHQKEPPFLWMGYELHPDKWT
VQPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVPLTAEAE
LELAENREILKEPVHGVYYDPSKELIAEVQKQG

References
Author Title Citation
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005