Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| PL42056 | 91776 | Portugal | 2003 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T+ 3TC+ IDV | 69 |
| 2 | D4T+ 3TC+ IDV+ ABC+ RTV | 206 |
| 3 | 3TC+ ABC+ IDV+ RTV | 2 |
| 4 | D4T+ TDF+ LPV | 63 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210LW, T215F | K20R, V35IT, T39E, S48T, K122E, D123S, I135T, T139TM, K173E, Q174QK, D177E, E194ED, G196K, T200A, I202V, Q207E, R211K, V241I, V245KR, E248D, D250E, A272P, K277R, E291D, I293V, I329V |
| >91776| codons 1-333 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICEELEKEGKITKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSTNNEMPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFREKNPEIVI YQYMDDLYVGSDLDIKQHRAKVEELREHLWKWGFFTPDKKHQKEPPFLWMGYELHPDKWT IQPIRLPDKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTDVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V82A | L10F, L24I, I54C | G17D, L19I, K20R, M36I, R41K, K45R, L63P, H69K, A71V, L89I, I93L |
| >91776| codons 1-99 PQITLWQRPFVTIKIGDQIREALIDTGADDTVLEEINLPGKWKPRMIGGIGGFCKVRQYD QIPIEICGKKVIGTVLVGPTPANIIGRNILTQLGCTLNF |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |