Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| PL4054 | 105535 | Portugal | 2004 | HIV1 | G | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ 3TC+ SQV | 30 |
| 2 | AZT+ 3TC+ SQV+ D4T+ IDV+ NFV | 25 |
| 3 | D4T+ 3TC+ IDV+ NFV+ NVP | 200 |
| 4 | D4T+ 3TC+ NVP+ IDV | 12 |
| 5 | D4T+ DDI+ EFV | 117 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, L90M | I13V, K14KR, I15V, K20T, E35D, M36I, R41K, I62V, H69K, T74S, V82I, L89I |
| >105535| codons 1-99 PQITLWQRPLVTVRVGGQLTEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFVKVRQYD QVLIEICGKKAIGSVLVGPTPINIIGRNIMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, V75VAIT, T215Y | K219E | L100LI, K103KN, V106VIM, Y188YC | V179VE | V35T, E44EA, V60I, S68G, T69TI, A98S, K122E, D123S, I135T, S162F, K173GIRV, Q174K, D177E, T200A, Q207K, R211S, D218DE, L228H, Q242QH, V245Q, E248D, D250E, A272P, T286A, E291ED, V292I, I293V, E297AT, I329V |
| >105535| codons 1-333 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEKAGKISKIGPENPYNTPI FAIKKKNGIRWRKLTDFRELNKRTQDFWEVQLGIPHPSGIKKNKSMTVLDVGDAYFSVPL DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQFSMTKILEPFRVKNPEIEI YQYMDDLCVGSDLEIGQHRAKIEELRKHLLSWGFYTPEEKHQKEPPFHWMGYELHPDKWT VHPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVPLTTEAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQG |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |