<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
PL4054 105535 Portugal 2004 HIV1 G Plasma None

Treatment History
Order Regimen Weeks
1 AZT+ 3TC+ SQV 30
2 AZT+ 3TC+ SQV+ D4T+ IDV+ NFV 25
3 D4T+ 3TC+ IDV+ NFV+ NVP 200
4 D4T+ 3TC+ NVP+ IDV 12
5 D4T+ DDI+ EFV 117

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, L90M   I13V, K14KR, I15V, K20T, E35D, M36I, R41K, I62V, H69K, T74S, V82I, L89I  
>105535| codons 1-99
PQITLWQRPLVTVRVGGQLTEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFVKVRQYD
QVLIEICGKKAIGSVLVGPTPINIIGRNIMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, T215Y V75VAIT, K219E L100LI, K103KN, V106VIM, Y188YC V179VE V35T, E44EA, V60I, S68G, T69TI, A98S, K122E, D123S, I135T, S162F, K173GIRV, Q174K, D177E, T200A, Q207K, R211S, D218DE, L228H, Q242QH, V245Q, E248D, D250E, A272P, T286A, E291ED, V292I, I293V, E297AT, I329V  
>105535| codons 1-333
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEKAGKISKIGPENPYNTPI
FAIKKKNGIRWRKLTDFRELNKRTQDFWEVQLGIPHPSGIKKNKSMTVLDVGDAYFSVPL
DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQFSMTKILEPFRVKNPEIEI
YQYMDDLCVGSDLEIGQHRAKIEELRKHLLSWGFYTPEEKHQKEPPFHWMGYELHPDKWT
VHPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVPLTTEAE
LELAENREILKEPVHGVYYDPSKDLIAEVQKQG

References
Author Title Citation
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005