<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
PL40509 77525 Portugal 2003 HIV1 G Plasma None

Treatment History
Order Regimen Weeks
1 AZT+ 3TC 74
2 D4T+ DDI+ NFV 171

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T215Y       V35T, T39K, K43R, V60I, A98S, K122E, D123S, I135T, A158AS, S162SN, K173I, Q174K, D177E, T200A, Q207K, R211S, V245Q, E248D, A272P, V276VA, T286A, E291D, V292I, I293V, E297A, I326L, I329V, K331N, Q334L  
>77525| codons 1-335
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICKELEREGKISKIGPENPYNTPI
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL
DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPSIFQNSMTKILEPFRIKNPEIVI
YQYMDDLYVGSDLEIGQHRAKIEELRKHLLSWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKAKQLCKLLRGAKALTDIVPLTAEAE
LELAENREILKEPVHGVYYDPSKDLLAEVQNQGLG

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54IL, L90M   I13V, K14R, K20T, E35D, M36I, R41K, I62IV, H69K, A71T, V82I, L89I  
>77525| codons 1-99
PQITLWQRPLVTVRIGGQLTEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFLKVRQYD
QVLIEICGKKTIGTVLVGPTPINIIGRNIMTQIGCTLNF

References
Author Title Citation
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005