Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| PL40388 | 105421 | Portugal | 2004 | HIV1 | G | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T+ 3TC+ IDV | 190 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I54V, V82T, I84V | L89MV | L10I, I13V, K14R, I15V, K20I, E35D, M36I, R41K, Q61QH, I62IV, L63LAPV, I66FL, H69K, A71AV, T74TS |
| >105421| codons 1-99 PQITLWQRPIVTVRVGGQLIEALLDTGADDTVLEDINLPGKWKPKIIGGIGGFVKVRQYD HVVIELCGKKVIGSVLVGPTPTNVIGRNVLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V | K219Q | V35T, K43KR, V60I, A98S, K122E, D123S, I135IT, K173R, Q174K, D177E, I195KT, T200A, R211NS, D218DE, V245Q, E248D, D250E, A272P, K275Q, V276T, K277R, T286A, E291D, V292I, I293V, E297A, D324E, I329V |
| >105421| codons 1-334 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEREGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRRKNPEIVI YQYVDDLYVGSDLETGQHRAKIEELRQHLLSWGFTTPEQKHQKEPPFLWMGYELHPDKWT VQPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIQTRQLCKLLRGAKALTDIVPLTAEAE LELAENREILKEPVHGVYYDPSKELIAEVQKQGQ |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |