<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
PL39651 67522 Portugal 2002 HIV1 G Plasma None

Treatment History
Order Regimen Weeks
1 AZT+ DDI 4
2 None 8
3 AZT+ 3TC+ EFV 21
4 AZT+ 3TC+ NFV 151

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V, T215TNSY   K103KN   E6D, V21I, V35T, V60I, A98S, K122E, D123S, I135V, Q174K, D177E, T200A, Q207E, R211S, V245Q, D250DE, A272P, T286A, E291D, V292I, I293V, E297A, D320E, D324E, I329V V254VI
>67522| codons 1-333
PISPIDTVPVKLKPGMDGPKIKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL
DESFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPEIVI
YQYVDDLYVGSDLEIGQHRAKIEELREHLLSWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKESWTINDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVPLTAEAE
LELAENREILKEPVHGVYYEPSKELIAEVQKQG

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, L90M   I13V, K14R, K20I, E35N, M36I, R41K, K45KR, I62IV, H69K, A71AV, T74S, V82VI, L89I  
>67522| codons 1-99
PQITLWQRPLVTVRIGGQLIEALLDTGADDTVLENINLPGKWKPRMIGGIGGFVKVRQYD
QVLIEICGKKVIGSVLVGPTPINIIGRNIMTQIGCTLNF

References
Author Title Citation
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005