Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| PL369 | 95591 | Portugal | 2004 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | Unknown | 52 |
| 2 | 3TC+LPV+TDF | 112 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54V, V82A, L90M | L33F, K43T | L10V, I15V, G16E, K20M, E35N, M36I, N37ND, R57K, Q61D, G68E, H69R, A71T, I72R, L89I, I93L |
| >95591| codons 1-99 PQITLWQRPVVTIKVEGQLMEALLDTGADDTVFENIDLPGRWTPKLIVGIGGFVKVKQYD DILIEICERKTRGTVLVGPTPANIIGRNIMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70KR, L210W, T215F | K219W | Y181C | V108VI | K20R, E28EK, V35M, T39K, K43E, K49KR, E53ED, K64Y, T69N, V118VI, D121Y, K122KE, D123DE, I135AT, S162DY, E169D, K173A, Q174K, D177E, Q207E, H208Y, R211K, L228H, Q242H, V245Q, E248D, A272P, T286A, A288T, E291D, V292I, I293V, E297A, V317A |
| >95591| codons 1-335 PISPIETVPVKLKPGMDGPRVKQWPLTKEKIKALMEICKELEEEGKISRIGPDNPYNTPV FAIYKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTILDVGDAYFSIPL YEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILDPFRAKNPEIVI CQYMDDLYVGSDLEIGQHRTKIEELREYLWKWGFFTPDWKHQKEPPFHWMGYELHPDKWT VHPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKTLTDIVPLTAEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGQG |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |