Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| pt-K | ptKW60 | U.S. | 1996 | HIV1 | B | PBMC | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | IDV | 60 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82F, L90M | Q58E | L10I, L63P, I64V, V77I, I93L |
| >ptKW60| 6 | codons 1-99 | clone 6 PQITLWQRPIVTIKMGGQLKEALLDTGADDTVLEEMSLPGRWKPKIIGGIGGFVKVREYD QIPVEICGHRAIGTVLIGPTPFNIIGRNLMTQLGCTLNF >ptKW60| 5 | codons 1-99 | clone 5 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVREYD QIPVEICGHKAIGTVLIGPTPFNIIGRNLMTQLGCTLNF >ptKW60| 4 | codons 1-99 | clone 4 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGSVKVREYD QIPVEICGHKAIGTVLIGPTPFNIIGRNLMTQLGCTLNF >ptKW60| 3 | codons 1-99 | clone 3 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVREYD QIPVEICGHKAIGTVLIGPTPFNIIGRNLMTQLGCTLNF >ptKW60| 2 | codons 1-99 | clone 2 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVREYD QIPVEICGHKAIGTVLIGPTPFNIIGRNLMTQLGCTLNF >ptKW60| 1 | codons 1-99 | clone 1 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVREYD QIPVEICGHKAIGTVLIGPTPFNIIGRNLMTQLGCTLNF >ptKW60| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVREYD QIPVEICGHKAIGTVLIGPTPFNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Condra, JH | Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor. | J Virol, 1996 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |