<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
pt-K ptKW60 U.S. 1996 HIV1 B PBMC MMC

Treatment History
Order Regimen Weeks
1 IDV 60

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82F, L90M Q58E L10I, L63P, I64V, V77I, I93L  
>ptKW60| 6 | codons 1-99 | clone 6
PQITLWQRPIVTIKMGGQLKEALLDTGADDTVLEEMSLPGRWKPKIIGGIGGFVKVREYD
QIPVEICGHRAIGTVLIGPTPFNIIGRNLMTQLGCTLNF
>ptKW60| 5 | codons 1-99 | clone 5
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVREYD
QIPVEICGHKAIGTVLIGPTPFNIIGRNLMTQLGCTLNF
>ptKW60| 4 | codons 1-99 | clone 4
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGSVKVREYD
QIPVEICGHKAIGTVLIGPTPFNIIGRNLMTQLGCTLNF
>ptKW60| 3 | codons 1-99 | clone 3
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVREYD
QIPVEICGHKAIGTVLIGPTPFNIIGRNLMTQLGCTLNF
>ptKW60| 2 | codons 1-99 | clone 2
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVREYD
QIPVEICGHKAIGTVLIGPTPFNIIGRNLMTQLGCTLNF
>ptKW60| 1 | codons 1-99 | clone 1
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVREYD
QIPVEICGHKAIGTVLIGPTPFNIIGRNLMTQLGCTLNF
>ptKW60| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVREYD
QIPVEICGHKAIGTVLIGPTPFNIIGRNLMTQLGCTLNF

References
Author Title Citation
Condra, JH Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor. J Virol, 1996
Wu, TD Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. J Virol, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005