Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| PL3275 | 91552 | Portugal | 2003 | HIV1 | CRF02_AG | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 274 |
| 2 | D4T+ 3TC+ SQV | 282 |
| 3 | AZT+ 3TC+ ABC | 21 |
| 4 | 3TC+ TDF+ NVP | 20 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54IV | L10IV, I13V, K20I, M36I, R41K, H69K, T74S, V75I, L89M |
| >91552| codons 1-99 PQITLWQRPVVTVKIGGQLIEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFVKVRQYD QILIEICGKKAIGSILVGPTPVNIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, M184V, T215F | K219Q | Y181YC, G190GA | A98AG | K11R, V35T, K43Q, V60I, K122E, D123DN, I135V, S162A, K173T, D177E, T200A, E203K, Q207E, R211K, V245K, D250E, S251H, T286A, E291D, V292I, I293V, P294T, V317VA, S322T |
| >91552| codons 1-334 PISPIETVPVRLKPGMDGPKVKQWPLTEEKIKALTEICTEMEQEGKISKIGPENPYNTPI FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRTQNPEIVI CQYVDDLYVASDLEIGQHRAKIKELREHLLKWGFFTPDQKHQKEPPFLWMGYELHPDKWT VQPIKLPEKEHWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDIVTLTEEAE LELAENREILKEPVHGAYYDPTKDLIAEIQKQGQ |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |