Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| PL32373 | 74841 | Portugal | 2002 | HIV1 | G | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ 3TC+ IDV | 26 |
| 2 | ABC+ EFV+ RTV+ NFV | 52 |
| 3 | D4T+ DDI+ NFV | 70 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, L90M | L89V | I13V, K14R, I15V, K20T, E35D, M36I, R41K, Q61E, H69K, K70R, V82I |
| >74841| codons 1-99 PQITLWQRPLVTVRVGGQLTEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFVKVRQYD EILIEICGKRAIGTVLVGPTPINIIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, D67N, K70KR, T215F | K219Q | K103N | P225PH | V35T, T39A, S48T, V60I, A98S, K122E, D123N, I135V, K173I, Q174K, D177E, I195K, G196E, T200A, R211S, V245Q, E248D, D250E, A272P, V276VI, L283LI, T286A, E291D, V292I, I293IV, E297A, E312DN, D324E, I329V |
| >74841| codons 1-334 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAELEKEGKITKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRIKNPEIVI YQYMDDLYVGSDLEKEQHRAKIEELRQHLLSWGFFTPDQKHQKEHPFLWMGYELHPDKWT VQPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKIKQLCKLIRGAKALTDIVPLTAEAE LELAENREILKNPVHGVYYDPSKELIAEVQKQGQ |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |