<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
PL1184 68323 Portugal 2002 HIV1 G Plasma None

Treatment History
Order Regimen Weeks
1 D4T+ DDI 196

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T215Y K219R     K20KR, V35T, T39E, K43R, E44D, V60I, T69TN, W88C, A98S, L109I, V118I, K122E, D123S, I135LV, Q174K, D177E, I195K, T200A, L210S, R211D, D218E, K223Q, L228R, V245Q, E248A, D250E, A272P, T286A, E291D, V292I, I293IV, E297A, L301M, D320E, D324E, I329V  
>68323| codons 1-334
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICEELERDGKISKIGPENPYNTPI
FAIKKKDSNKWRKLVDFRELNKRTQDFCEVQLGIPHPSGLKKKKSVTVIDVGDAYFSIPL
DESFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPEIVI
YQYMDDLYVGSDLEKGQHRAKIEELRQHLSDWGFYTPERKHQQEPPFRWMGYELHPDKWT
VQPIQLPAKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVPLTAEAE
MELAENREILKEPVHGVYYEPSKELIAEVQKQGQ

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I13V, K14R, I15V, K20I, E35D, M36I, R41K, H69K, K70R, V82I, L89M  
>68323| codons 1-99
PQITLWQRPLVTVRVGGQLIEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD
QILIEICGKRAIGTVLVGPTPINIIGRNMLTQIGCTLNF

References
Author Title Citation
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005