<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
PL10146 83346 Portugal 2003 HIV1 G Plasma None

Treatment History
Order Regimen Weeks
1 EFV+ IDV+ RTV 151

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
    Y188L V179E V35T, V60I, A98S, K122E, D123S, I135T, T139I, E169EG, K173I, Q174K, D177E, T200A, R211S, V245Q, E248D, D250E, A272P, V276I, T286A, E291D, V292I, I293V, E297AV  
>83346| codons 1-313
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL
DESFRKYTAFTIPSTNNEIPGIRYQYNVLPQGWKGSPAIFQSSMTKILGPFRIKNPEIEI
YQYMDDLLVGSDLEIGQHRAKIEELRQHLLSWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKIKQLCKLLRGAKALTDIVPLTVEAE
LELAENREILKEP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82T   I13V, K14R, K20I, E35D, M36I, N37ND, R41K, I62V, I66F, H69K, L89M  
>83346| codons 1-99
PQITLWQRPLVTVRIGGQLIEALLDTGADDTVLEDIDLPGKWKPKIIGGIGGFVKVRQYD
QVLIEFCGKKAIGTVLVGPTPTNIIGRNMLTQIGCTLNF

References
Author Title Citation
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005