Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| PL26473 | 89488 | Portugal | 2003 | HIV1 | G | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | NFV+ SQV+ RTV+ IDV+ EFV+ 3TC+ DDI+ AZT | NA |
| 2 | 3TC+ LPV+ ABC | NA |
| 3 | Unknown | 124 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, V75M, M184V, T215Y | K219Q | V35T, E44A, V60I, A98S, S117A, K122E, D123S, I135T, I167IV, K173IT, Q174K, D177G, G196E, T200A, E203K, Q207E, H208Y, R211H, W212L, D218E, L228H, V245Q, E248D, D250E, A272P, T286A, E291D, V292VI, I293V, E297A, L301M, D324E, I329V, Q334P |
| >89488| codons 1-335 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEKAGKISKIGPENPYNTPI FAIKKKNSTRWRKLMDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFAVPL DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKVLEPFRTKNPGIVI YQYVDDLYVGSDLEIEQHRAKIKELREYLLHLGFYTPEQKHQKEPPFHWMGYELHPDKWT VQPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVPLTAEAE MELAENREILKEPVHGVYYDPSKELIAEVQKQGPG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V, I54V, V82F, L90M | L89V | L10I, I13A, K14R, K20IT, A22AV, E35N, M36I, N37D, R41K, L63P, I66V, H69K, K70KT, A71V, I85IV, Q92K | C67CR |
| >89488| codons 1-99 PQITLWQRPIVTARIGGQLTEVLLDTGADDTVLENIDLPGKWKPKIIGGVGGFVKVRQYD QIPIEVRGKTVIGTVLVGPTPFNIVGRNVMTKIGCTLNF |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |