Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5949 | CA57703 | U.S. | 2005 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | 52 |
| 2 | 3TC+AZT+RTV+SQV | 26 |
| 3 | 3TC+APV+AZT+RTV | 35 |
| 4 | ABC+D4T+DDI+EFV | 57 |
| 5 | ABC+D4T+DDI | 219 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V, L90M | L10I, I62IV, L63AV, A71V, I72V, V77I, I93L | T26TA, T31TA |
| >CA57703| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDAGADDAVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QVVIEICGHKVVGTVLIGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69T_T, K70R | K219Q | K103KN | A98G, V108I | V35I, T39TA, K64N, K102KR, D121C, K122E, K166R, Q174QH, D177E, G196E, E203K, Q207E, R211K, F214FL, H221Y, L228N, V245T, A272P, K277R, I293V |
| >CA57704| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAEMEKEGKISKIGPENPYNTPV FAINKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKRNKSVTILDVGDAYFSVPL CEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKHNPEIVI YQYMDDLYVGSDLEIEQHRTKIKELREHLLKWGLTTPDQKYQKEPPFNWMGYELHPDKWT VQPITLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTEEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 protease mutations and protease inhibitor cross resistance. | AAC, 2010 |