Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5471 | CA57701 | U.S. | 2005 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDC | 78 |
| 2 | 3TC+AZT | 39 |
| 3 | 3TC+AZT+IDV | 39 |
| 4 | D4T+DDI+RTV+SQV | 56 |
| 5 | D4T+DDI+IDV+RTV | 104 |
| 6 | D4T+DDI+EFV | 39 |
| 7 | ABC+APV+DDI+LPV | 74 |
| 8 | Unknown | 157 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, V82A | L10F, L24I, L33F | I13V, L19I, K55R, L63P, A71V, I93L, L97I |
| >CA57701| codons 1-99 PQITLWQRPFVTVKIGGQIKEALIDTGADDTVFEEMNLPGRWKPKIIGGIGGFVRVRQYD QIPIEICGHKVIGTVVVGPTPANIIGRNLLTQLGCTINF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70GRS, M184V, T215F | K219Q | K103KN | K20R, V60I, K122P, D177E, G196E, D218E, V245T, K277R, L283LI, T286A, A288S, I293V, P294T, E297K |
| >CA57702| codons 1-301 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI FAIKKKNSTSWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DPDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGFFTPEQKHQKEPPFLWMGYELHPDKWT VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLIRGAKSLTEVVTLTKEAE L |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 protease mutations and protease inhibitor cross resistance. | AAC, 2010 |