Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| pt-P | ptPW48 | U.S. | 1996 | HIV1 | B | PBMC | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | IDV | 48 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, V82F, I84V | L33I | L10I, T12S, I13V, M36I, I64V, L89M |
| >ptPW48| 6 | codons 1-99 | clone 6 PQITLWQRPIVSVKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVRQYD QILVEICGHKAIGTVLVGPTPFNVIGRNMLTQIGCTLNF >ptPW48| 5 | codons 1-99 | clone 5 PQITLWQRPIVSVKIGGQLKEALLDTGADDTVIEEINLPGRWKPKIIGGIGGFIKVRQYD QILVEICGHKAIGTVLVGPTPFNVIGRNMLTQIGCTLNF >ptPW48| 4 | codons 1-99 | clone 4 PQITLWQRPIVSVKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVRQYD QILVEICGHKAIGTVLVGPTPFNVIGRNMLTQIGCTLNF >ptPW48| 3 | codons 1-99 | clone 3 PQITLWQRPIVSVKIGGQLKEALLDTGADDTVIEEINLPGRWKPKIIGGIGGFIKVRQYD QILVKICGHKAIGTVLVGPTPFNVIGRNMLTQIGCTLNF >ptPW48| 2 | codons 1-99 | clone 2 PQITLWQRPIVSVKIGGQLKEALLDTGADDTVIEEINLPGRWKPKIIGGIGGFIKVRQYD QILVEICGHKAIGTVLVGPTPFNVIGRNMLTQIGCTLNF >ptPW48| 1 | codons 1-99 | clone 1 PQITLWLRPIVSVKIGGQLKEALLDTGADDTVIEEINLPGRWKPKIIGGIGGFIKVRQYD QILVEICGHKAIGTVLVGPTPFNVIGRNMLTQIGCTLNF >ptPW48| codons 1-99 PQITLWQRPIVSVKIGGQLKEALLDTGADDTVIEEINLPGRWKPKIIGGIGGFIKVRQYD QILVEICGHKAIGTVLVGPTPFNVIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Condra, JH | Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor. | J Virol, 1996 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |