Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA7106 | CA57607 | U.S. | 2005 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+3TC | 139 |
| 2 | D4T+DDI+EFV | 44 |
| 3 | 3TC+D4T+DDI+NFV | 9 |
| 4 | 3TC+DDI+NFV | 69 |
| 5 | 3TC+DDI+NFV+RTV | 168 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N, M46I, I54L, L90M | L33F, K43KT, N88D | L19LI, I62V, L63P, I66L, A71T, I72IT, V77I, V82I, I93L |
| >CA57607| codons 1-99 PQITLWQRPLVTIKIGGQIKEALLDTGADNTVFEEMNLPGRWTPKIIGGIGGFLKVRQYD QVPIELCGHKTTGTVLIGPTPINIIGRDLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, T215Y | V118I, K122E, T200I, Q207E, E248EK, K277KR, Q278H, R284K, I293V, P294T, E297K | S68SDGN |
| >CA57608| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDNTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRIKIEELREHLLRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPKKDSWTVNDIQKLVGKLNWASQIYAGIKVRHLCKLLKGTKALTEVVTLTKEAE |
References
| Author | Title | Citation |
| Mitsuya, Y | N88D facilitates the co-occurrence of D30N and L90M and the development of multidrug resistance in HIV type 1 protease following nelfinavir treatment failure. | ARHR, 2006 |