Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| DK-9415 | 6367_d224 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | SQV+ RTI | 7 |
| 2 | RTV+ RTI | 80 |
| 3 | IDV+ RTI | 6 |
| 4 | RTV+ IDV+ RTI | 40 |
| 5 | LPV+NRTI+NVP | 32 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, T215F | K219Q | L100I, K103N | V35T, K102R, I135V, S162SC, E169D, K173A, Q174K, I178L, Q207A, R211K, L228H, V245Q, E248D, A272P, T286A, E291D, V292I, E297T |
| >6367_d224| codons 1-311 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKRNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILDPFRAKNPDLVI YQYMDDLYVGSDLEIGQHRTKIEELRAHLLKWGFFTPDQKHQKEPPFHWMGYELHPDKWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIIPLTTEAE LELAENREILK |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32VI, M46MI, I47IV, I50IV, I54AV, V82A, L90M | G73GS | L10LI, I15V, G16E, K20R, E35D, M36I, R41K, K55KR, R57K, Q61DN, A71V, I72R, L89LFIM, Q92QK |
| >6367_d224| codons 1-99 PQITLWQRPLVTIKVEGQLREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFAKVKQYD DILIEICGHKVRGTVLVGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Kempf, DJ | Identification of genotypic changes in human immunodeficiency virus protease that correlate with reduced susceptibility to the protease inhibitor lopinavir among viral isolates from protease inhibitor-experienced patients. | J Virol, 2001 |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |