<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 SQV+ RTI 7
2 RTV+ RTI 80
3 IDV+ RTI 6
4 RTV+ IDV+ RTI 40
5 LPV+NRTI+NVP 20

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, T69D, K70R, T215F K219Q L100I, K103N   V35T, K102R, I135L, E169D, K173A, Q174K, I178L, Q207A, R211K, L228H, V245Q, E248D, A272P, T286A, E291D, V292I, E297T  
>6367_d140| codons 1-311
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV
FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKRNKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRAKNPDLVI
YQYMDDLYVGSDLEIGQHRTKIEELRAHLLKWGFFTPDQKHQKEPPFHWMGYELHPDKWT
VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIIPLTTEAE
LELAENREILK

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54A, V82A, L90M   L10I, I15V, G16E, K20R, E35D, M36I, R41K, R57K, Q61D, A71V, I72R, L89I, Q92K  
>6367_d140| codons 1-99
PQITLWQRPIVTIKVEGQLREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFAKVKQYD
DILIEICGHKVRGTVLVGPTPANIIGRNIMTKIGCTLNF

References
Author Title Citation
Kempf, DJ Identification of genotypic changes in human immunodeficiency virus protease that correlate with reduced susceptibility to the protease inhibitor lopinavir among viral isolates from protease inhibitor-experienced patients. J Virol, 2001
Melikian, GL Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. AAC, 2012