Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| DK-7815 | 6373_d493 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | IDV+ RTI | 21 |
| 2 | RTV+ RTI | 34 |
| 3 | SQV+ NFV+ RTI | 35 |
| 4 | SQV+ RTV+ RTI | 29 |
| 5 | SQV+ NFV+ RTI | 46 |
| 6 | LPV+NRTI+NVP | 70 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70G, Y115F, Q151M, M184I, T215Y | A62V, V75I, F77L, F116Y | K103N, Y188H | P1L, K20R, T58N, S68N, K101KQ, K122E, I135T, I167IV, V179I, I202V, L210LS, R211K, T286A, E297K |
| >6373_d493| codons 1-311 LISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNNPV FVIKKKNNTGWRKLIDLRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAFYSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYIDDLHVGSDLEIGQHRTKVEELRQHLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTKEAE LELAENREILK |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I47IV, I54V, V82A, L90M | L33F, F53L, G73S | T4TP, L10IV, I13V, K14R, K20R, E34EV, E35D, M36I, R41K, K55KR, D60E, Q61G, I62V, L63P, A71V |
| >6373_d493| codons 1-99 PQITLWQRPIVTVRIGGQLREALLDTGADDTVFEDINLPGKWKPKMIGGIGGLVKVRQYE GVPIEICGHKVISTVLVGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Kempf, DJ | Identification of genotypic changes in human immunodeficiency virus protease that correlate with reduced susceptibility to the protease inhibitor lopinavir among viral isolates from protease inhibitor-experienced patients. | J Virol, 2001 |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |