<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 NFV+ RTI 133
2 LPV+NRTI+NVP 48

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, L76V, L90M L33F, N88G L10I, I13V, G16GA, Q18H, N37D, Q61H, L63P, A71L, I72T, V77I, I93L  
>8362_d337| codons 1-99
PQITLWQRPIVTVKIGGHLKEALLDTGADDTVFEEMDLPGRWKPKIIGGIGGFVKVRQYD
HIPIEICGHKLTGTVVIGPTPVNIIGRGLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
L74V, M184V, T215Y V75A, K219E G190C   K73M, R83K, K101Q, V118I, D123G, I178L, V189I, T286TA, I293V, E297A, D324E, R358K, E399D K49T
>8362_d337| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISTIGPENPYNTPV
FAIKKKDSTKWRMVADFRELNKKTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSIPL
DKGFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI
YQYVDDLYICSDLEIGQHRTKIEELRQHLLRWGFYTPDEKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVPLTAEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMKGA
HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWDA

References
Author Title Citation
Kempf, DJ Identification of genotypic changes in human immunodeficiency virus protease that correlate with reduced susceptibility to the protease inhibitor lopinavir among viral isolates from protease inhibitor-experienced patients. J Virol, 2001