Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| DK-2314 | 8362_d337 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | NFV+ RTI | 133 |
| 2 | LPV+NRTI+NVP | 48 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, L90M | L33F, N88G | L10I, I13V, G16GA, Q18H, N37D, Q61H, L63P, A71L, I72T, V77I, I93L |
| >8362_d337| codons 1-99 PQITLWQRPIVTVKIGGHLKEALLDTGADDTVFEEMDLPGRWKPKIIGGIGGFVKVRQYD HIPIEICGHKLTGTVVIGPTPVNIIGRGLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L74V, M184V, T215Y | V75A, K219E | G190C | K73M, R83K, K101Q, V118I, D123G, I178L, V189I, T286TA, I293V, E297A, D324E, R358K, E399D | K49T |
| >8362_d337| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISTIGPENPYNTPV FAIKKKDSTKWRMVADFRELNKKTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSIPL DKGFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI YQYVDDLYICSDLEIGQHRTKIEELRQHLLRWGFYTPDEKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVPLTAEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMKGA HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWDA |
References
| Author | Title | Citation |
| Kempf, DJ | Identification of genotypic changes in human immunodeficiency virus protease that correlate with reduced susceptibility to the protease inhibitor lopinavir among viral isolates from protease inhibitor-experienced patients. | J Virol, 2001 |