<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 PI+ NRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69D, M184V, L210W, T215Y K219R K103KN, V106VA, Y181YC   T39A, E44D, V118I, K122E, I142V, S162FY, E203K, Q207E, H208HY, R211K, K223E, E224K, L228LH, Q242K, A288AS, E297K  
>9182_d1| codons 1-311
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPV
FAIKKKDSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQFSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRTKIKELREHLWKWGFYTPDRKHQEKPPFLWMGYELHPDKWT
VKPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVIPLTKEAE
LELAENREILK

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A, L90M G73GC L10I, T12TK, E35D, M36MI, I62V, L63P, I64IV, T74S, I93L, C95F  
>9182_d1| codons 1-99
PQITLWQRPIVKIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKIIGGIGGFVKVRQYD
QVPVEICGHKAICSVLVGPTPANIIGRNLMTQLGFTLNF

References
Author Title Citation
Mo, H Selection of resistance in protease inhibitor-experienced, human immunodeficiency virus type 1-infected subjects failing lopinavir- and ritonavir-based therapy: mutation patterns and baseline correlates. J Virol, 2005
Melikian, GL Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. AAC, 2012