Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI+ NRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | G73GC | L10I, T12TK, E35D, M36MI, I62V, L63P, I64IV, T74S, I93L, C95F |
| >9182_d1| codons 1-99 PQITLWQRPIVKIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKIIGGIGGFVKVRQYD QVPVEICGHKAICSVLVGPTPANIIGRNLMTQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, M184V, L210W, T215Y | K219R | K103KN, V106VA, Y181YC | T39A, E44D, V118I, K122E, I142V, S162FY, E203K, Q207E, H208HY, R211K, K223E, E224K, L228LH, Q242K, A288AS, E297K |
| >9182_d1| codons 1-311 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPV FAIKKKDSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQFSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIKELREHLWKWGFYTPDRKHQEKPPFLWMGYELHPDKWT VKPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVIPLTKEAE LELAENREILK |
References
| Author | Title | Citation |
| Mo, H | Selection of resistance in protease inhibitor-experienced, human immunodeficiency virus type 1-infected subjects failing lopinavir- and ritonavir-based therapy: mutation patterns and baseline correlates. | J Virol, 2005 |
| King, M | Phenotypic susceptibility to TMC-114 and tipranavir before and after lopinavir/ritonavir-based treatment in subjects demonstrating evolution of lopinavir resistance. | IHDRW 2006, 2006 |