Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 8985 | 8985_d330 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI+ NRTI | NA |
| 2 | LPV+ NVP+ NRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L210W, T215Y | V75M, K219HQ | K103N, V106A | F227L | T39A, K43E, E44A, V60I, T69N, K102KR, V118I, K122E, I135V, I142V, D177N, I178M, G196E, E203EA, H208Y, D218E, V245K |
| >8985_d330| codons 1-311 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEEAGKISKIGPENPYNTPI FAIKKKNSNRWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKNKSATVLDVGDAYFSIPL DEDFRKYTAFTIPSVNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPNMVI YQYMDDLYVGSDLEIEQHRTKIEELRQYLWRWGFYTPEHKHQKEPPLLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVIPLTEEAE LELAENREILK |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | G73S | L10I, K20KR, E35D, M36I, I62V, L63P, A71V, I93L |
| >8985_d330| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKIIGGIGGFVKVRQYD QVPIEICGHKVISTVLVGPTPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Mo, H | Selection of resistance in protease inhibitor-experienced, human immunodeficiency virus type 1-infected subjects failing lopinavir- and ritonavir-based therapy: mutation patterns and baseline correlates. | J Virol, 2005 |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |