Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| WJ_pat7728 | 7728_W32 | U.S. | 2002 | HIV1 | B | PBMC | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | TDF+ 3TC+ EFV | 32 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, I15V, L19I, R41K, D60E, Q61E, L63V, H69Q, V77I |
| >7728_W32| codons 1-99 PQITLWQRPIVTIKVGGQIKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYE EIVIEICGQKAIGTVLIGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, M184V | A62V | Y188L | K102Q, D123E, I135T, S162C, V179I, I195T, T200A, V245M, T286A, P294A, T296S, E297K |
| >7728_W32| codons 1-297 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FVIKRKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKQKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIII YQYVDDLLVGSDLETGQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIALSK |
References
| Author | Title | Citation |
| Weber, J | Diminished replicative fitness of primary human immunodeficiency virus type 1 isolates harboring the K65R mutation. | J Clin Microbiol, 2005 |