Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| WJ_pat7225 | 7225_W36 | U.S. | 2002 | HIV1 | B | PBMC | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T+ 3TC+ EFV | 35 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R | L100I, K103N | D123E, K173E, D177E, I178M, T200A, E204K, Q207A, R211K, P243T, A272P |
| >7225_W36| codons 1-296 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKRKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFREQNPEMVI YQYMDDLYVGSDLEIGQHRAKIEKLRAHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQTIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLT |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, I15V, L19I, E35D, N37D, L63P, I93L |
| >7225_W36| codons 1-99 PQITLWQRPLVSIKVGGQIKEALLDTGADDTVLEDMDLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Weber, J | Diminished replicative fitness of primary human immunodeficiency virus type 1 isolates harboring the K65R mutation. | J Clin Microbiol, 2005 |