Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| WJ_pat7152 | 7152_W36 | U.S. | 2002 | HIV1 | B | PBMC | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T+ 3TC+ EFV | 35 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, T69~, K70R | V106M | V179D | K20R, V35L, K43S, I50V, R83K, D121H, K122E, E169D, D177E, F214L, E248D, A272P, K277R, T286A |
| >7152_W36| codons 1-298 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICTEMESEGKISKVGPENPYNTPV FAIKRKDS~RWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSMTVLDVGDAYFSVPL HEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPEIDI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTEE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M36I, L63P |
| >7152_W36| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Weber, J | Diminished replicative fitness of primary human immunodeficiency virus type 1 isolates harboring the K65R mutation. | J Clin Microbiol, 2005 |