<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
ACTG320_997 997 U.S. 1996 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 14
2 AZT+ NVP+ DDI 79
3 AZT+ DDI 1

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41ML, D67N, K70R, T215FY K219E, N348I K103N, Y181C   I50V, S162SDGN, E169D, Q197E, T200I, L228H, S251N, K277R, L283LI, I293V, K366R, A400AT, E404D, V435A, A437V, Q487X I159IL
>997| codons 1-487
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKVGPENPYNTPV
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPALFQNSMTKILDPFRKQNPDIVI
CQYMDDLYVGSDLEIGEHRIKIEELRQHLLRWGFYTPDEKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDNWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLIRGTKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKILKTGKYARMRGA
HTNDVRQLTEAVQKIATESIVIWGKTPKFKLPIQKETWETWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIAGVETFYVDGAANRETKLGKAGYVTDRGRQKVVSLTDTTNQKTELQ
AIHLALH

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I15IV, I64V  
>997| codons 1-99
PQITLWQRPLVTIKVGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
QILVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF

References
Author Title Citation
Hammer, SM A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. N Engl J Med, 1997