<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
ACTG320_984 984 U.S. 1996 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 213
2 AZT+ DDI 127

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L74LI, L210W, T215Y K219Q     E44D, V60I, V118VI, K122P, I135IV, S162DN, K166KR, D177E, I178ILM, G196E, T200TI, D218DE, E248D, A272P, K277R, T286TA, I293V, E297K, L301I, A304E, R356RK, A360AT, A371V, I375IV, A376T, K390KR, K395KR, A400S, V435M, K451KN, V458VI, D460N, R461RK, V467I, T470TA, L486X  
>984| codons 1-486
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPI
FAIKKKNSTRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DPDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQNSMTRILEPFRKQNPEMVI
YQYMDDLYVGSDLEIEQHRIKIEELRQHLWRWGFYTPEQKHQKEPPFLWMGYELHPDKWT
VQPIVLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVVPLTKEAE
IELEENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRGT
HTNDVKQLTEVVQKVTTESIVIWGKTPKFRLPIQRETWESWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIMGAETFYVDGAANRETNLGKAGYITNKGRQKVISLADTTNQKTELQ
AIHLAF

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    L63P  
>984| codons 1-99
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF

References
Author Title Citation
Hammer, SM A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. N Engl J Med, 1997