<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
ACTG320_978 978 U.S. 1996 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 13
2 AZT+ DDI 69
3 AZT 52
4 None 16

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        T39TA, A98S, K122KE, I135RT, K173N, Q207QH, R211K, F214L, V245VM, L283I, I293V, E297A, K311R, G333E, Q334H, M357T, T377K, K390R, E404D, L452I, L469I, T470TN, L486X  
>978| codons 1-486
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRNQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRHHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLIRGTKALTEVVPLTAEAE
LELAENREILREPVHGVYYDPSKDLIAEIQKQEHGQWTYQIYQEPFKNLKTGKYARTRGA
HTNDVKQLTEAVQKIAKESIVIWGKTPKFRLPIQKETWEAWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKIGKAGYVTDRGRQKVVSINDTTNQKTELQ
AIHLAF

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12K, L19LQ, R41K, L63P, V77I, I93L  
>978| codons 11-99
VKIKIGGQQKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYDQIPIEICGHK
AIGTVLIGPTPVNIIGRNLLTQLGCTLNF

References
Author Title Citation
Hammer, SM A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. N Engl J Med, 1997