<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
ACTG320_925 925 U.S. 1996 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 116
2 None 24
3 DDI 45

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
L74V, L210W T215D Y181C   S68G, R83K, V90I, D123E, K166KR, I178M, R211K, S251V, K277R, T286A, V292I, D324E, Q334L, K347KR, T377Q, T386TA, K390R, A400L, V435A, K451R, R461RK  
>925| codons 1-488
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDGTKWRKVVDFRELNKKTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDMVI
CQYMDDLYVGSDLEIGQHRTKIEELRQHLWKWGFDTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDVWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTEIIPLTEEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGLGQWTYQIYQEPFRNLKTGKYARMRGA
HTNDVKQLTEAVQKIAQESIVIWGKAPKFRLPIQKETWELWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIAGAETFYVDGAANRETRLGKAGYVTDKGRQKVVSLTDTTNQKTELQ
AIHLALQD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    E35D, N37ST, I64V  
>925| codons 1-99
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDMTLPGRWKPKMIGGIGGFIKVRQYD
QILVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF

References
Author Title Citation
Hammer, SM A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. N Engl J Med, 1997