Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ACTG320_925 | 925 | U.S. | 1996 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 116 |
| 2 | None | 24 |
| 3 | DDI | 45 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L74V, L210W | T215D | Y181C | S68G, R83K, V90I, D123E, K166KR, I178M, R211K, S251V, K277R, T286A, V292I, D324E, Q334L, K347KR, T377Q, T386TA, K390R, A400L, V435A, K451R, R461RK |
| >925| codons 1-488 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDGTKWRKVVDFRELNKKTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDMVI CQYMDDLYVGSDLEIGQHRTKIEELRQHLWKWGFDTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDVWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTEIIPLTEEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGLGQWTYQIYQEPFRNLKTGKYARMRGA HTNDVKQLTEAVQKIAQESIVIWGKAPKFRLPIQKETWELWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIAGAETFYVDGAANRETRLGKAGYVTDKGRQKVVSLTDTTNQKTELQ AIHLALQD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| E35D, N37ST, I64V |
| >925| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDMTLPGRWKPKMIGGIGGFIKVRQYD QILVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Hammer, SM | A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. | N Engl J Med, 1997 |