Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ACTG320_896 | 896 | U.S. | 1996 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 65 |
| 2 | None | 16 |
| 3 | DLV | 27 |
| 4 | DLV+ DDC+ AZT | 50 |
| 5 | DDC+ AZT | 3 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | K219N | K103N, Y181C | V35I, T39A, K43E, E44EA, K122E, G196E, T200I, H208HY, R211K, L228R, P294Q, Q334E, A360T, A376T, T386A, A400T, I434L, V435E, A437AV, D460N, R461K, V467VI, S468T, Q480H, H483Y | E40DFVY |
| >896| codons 1-489 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAYLEEAGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYVGSDLEIEQHRIKIEELRQYLWKWGFYTPDNKHQKEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVIQLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARMRGT HTNDVKQLTEAVQKITTESIVIWGKAPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPLEGVETFYVDGAANRETKLGKAGYVTNKGRQKVITLTDTTNQKTELH AIYLALQDS |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L33LV, E35ED, N37X, L63P, I64V |
| >896| codons 9-99 PLVTIKIGGQLKEALLDTGADDTVVEDMXLPGRWKPKMIGGIGGFIKVRQYDQIPVEICG HKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Hammer, SM | A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. | N Engl J Med, 1997 |