<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
ACTG320_896 896 U.S. 1996 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 65
2 None 16
3 DLV 27
4 DLV+ DDC+ AZT 50
5 DDC+ AZT 3

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L210W, T215Y K219N K103N, Y181C   V35I, T39A, K43E, E44EA, K122E, G196E, T200I, H208HY, R211K, L228R, P294Q, Q334E, A360T, A376T, T386A, A400T, I434L, V435E, A437AV, D460N, R461K, V467VI, S468T, Q480H, H483Y E40DFVY
>896| codons 1-489
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAYLEEAGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
CQYMDDLYVGSDLEIEQHRIKIEELRQYLWKWGFYTPDNKHQKEPPFRWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVIQLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARMRGT
HTNDVKQLTEAVQKITTESIVIWGKAPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPLEGVETFYVDGAANRETKLGKAGYVTNKGRQKVITLTDTTNQKTELH
AIYLALQDS

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    L33LV, E35ED, N37X, L63P, I64V  
>896| codons 9-99
PLVTIKIGGQLKEALLDTGADDTVVEDMXLPGRWKPKMIGGIGGFIKVRQYDQIPVEICG
HKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF

References
Author Title Citation
Hammer, SM A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. N Engl J Med, 1997