<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
ACTG320_886 886 U.S. 1996 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 26
2 None 72
3 DDI 56
4 DDI+ AZT 138
5 None 15

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41ML, D67DN, K70KR, L74V, T215TFIS K219KQ Y181YC   K104KN, V118VI, D123E, I135T, D177DE, I178IM, G196E, R211G, F214L, D218DE, A272P, K277KR, I293V, K311R, S322T, T338S, M357MT, R358RK, K395R, A400S, E404D, E432ED, V466VA, T470N, D488X V60VIM, K64KHNQ
>886| codons 1-488
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPM
FAIQKKNSTRWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKNSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI
CQYMDDLYVGSDLEIEQHRTKIEELRQHLLGWGLSTPEQKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTEEAE
LELAENREILREPVHGVYYDPTKDLIAEIQKQGQGQWSYQIYQEPFKNLKTGKYARTKGA
HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQRETWESWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKDPIVGAETFYVDGAANRETKLGKAGYVTDRGRQKAVSLNDTTNQKTELQ
AIHLALQE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I15V, L19IV, E35D, N37D, L63P, I93L  
>886| codons 1-99
PQITLWQRPLVTIKVGGQVKEALLDTGADDTVLEDMDLPGRWKPKMIGGIGGFIKVRQYD
QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF

References
Author Title Citation
Hammer, SM A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. N Engl J Med, 1997