Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ACTG320_883 | 883 | U.S. | 1996 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 3 |
| 2 | AZT+ DDC | 59 |
| 3 | AZT+ DDI+ NVP | 90 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74LI, L210W, T215Y | K219N | Y181C, G190A | K43E, E44A, V118I, K122E, D123E, A158S, T200TI, R211K, V245I, A272P, K277R, I293V, I326V, Q334N, R356K, R358K, G359S, A371V, I375V, E399ED, T403M, I482V |
| >883| codons 1-486 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPV FAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPSIFQSSMTKILEPFRKQNPDIVI CQYMDDLYVASDLEIGQHRIKIEELRQHLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIILPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLVAEIQKQGNGQWTYQIYQEPFKNLKTGKYAKMKSA HTNDVKQLTEVVQKVATESIVIWGKTPKFKLPIQKETWDAWWMEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTDRGRQKVVSLTDTTNQKTELQ AVHLAL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I13V, R41K, L63H, V77I |
| >883| codons 1-99 PQITLWQRPLVTVKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QIHIEICGHKAIGTVLIGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Hammer, SM | A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. | N Engl J Med, 1997 |