Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ACTG320_857 | 857 | U.S. | 1996 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 11 |
| 2 | AZT+ DDI | 17 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T215Y | E53D, K64KR, A98AS, K104KN, K122KE, E138A, T286A, A288S, K311R, Q334E, M357S, T369TA, A376T, E399D, A400T, T403S, V435VA, F440FY, A446AS, Q480X |
| >857| codons 1-480 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPDNPYNTPV FAIRKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKNSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKSLTEVIPLTEEAE LELAENREILREPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARSRGA HTNDVKQLAEAVQKITTESIVIWGKTPKFKLPIQKETWDTWWSEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIAGAETYYVDGASNRETKLGKAGYVTDRGRQKVVSLTDTTNQKTELH |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10LIV, I13IV, N37ST, L63P, I64L, V77I |
| >857| codons 6-99 WQRPVVTVKIGGQLKEALLDTGADDTVLEEMTLPGRWKPKMIGGIGGFIKVRQYDQIPLE ICGHKAIGTVLIGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Hammer, SM | A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. | N Engl J Med, 1997 |