<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
ACTG320_857 857 U.S. 1996 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 11
2 AZT+ DDI 17

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T215Y       E53D, K64KR, A98AS, K104KN, K122KE, E138A, T286A, A288S, K311R, Q334E, M357S, T369TA, A376T, E399D, A400T, T403S, V435VA, F440FY, A446AS, Q480X  
>857| codons 1-480
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPDNPYNTPV
FAIRKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKNSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKSLTEVIPLTEEAE
LELAENREILREPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARSRGA
HTNDVKQLAEAVQKITTESIVIWGKTPKFKLPIQKETWDTWWSEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIAGAETYYVDGASNRETKLGKAGYVTDRGRQKVVSLTDTTNQKTELH

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    L10LIV, I13IV, N37ST, L63P, I64L, V77I  
>857| codons 6-99
WQRPVVTVKIGGQLKEALLDTGADDTVLEEMTLPGRWKPKMIGGIGGFIKVRQYDQIPLE
ICGHKAIGTVLIGPTPVNIIGRNLLTQIGCTLNF

References
Author Title Citation
Hammer, SM A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. N Engl J Med, 1997