Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ACTG320_536 | 536 | U.S. | 1996 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI+ DLV | 30 |
| 2 | DLV+ DDC+ AZT | 49 |
| 3 | DDC+ AZT | 4 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67DN, K70R, T215Y | K219E, N348I | K103KN, Y181C | K49R, I135T, Q145C, E169D, Q197E, L228R, K311R, R358K, G359GS, K385R, K390R, T470P, E492X |
| >536| codons 1-492 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYCYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPDIVI CQYMDDLYVGSDLEIGEHRTKIEELRQHLLRWGFYTPDEKHQKEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVIPLTEEAE LELAENREILREPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKILKTGKYARMKSA HTNDVKQLTEAVQKIATESIVIWGRTPKFRLPIQKETWEAWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTDRGRQKVVSLPDTTNQKTELQ AIHLALQDSGLD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12TS, K14R, I15IV, L19S, R41K, L63LP, I64IV |
| >536| codons 1-99 PQITLWQRPLVSIRVGGQSKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QIPVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Hammer, SM | A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. | N Engl J Med, 1997 |