Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ACTG320_453 | 453 | U.S. | 1996 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 52 |
| 2 | None | 52 |
| 3 | DDI | 52 |
| 4 | None | 210 |
| 5 | AZT | 8 |
| 6 | AZT+ D4T | 4 |
| 7 | AZT | 17 |
| 8 | AZT+ 3TC | 1 |
| 9 | AZT | 2 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K219N | Y181C | V179E | V35VL, T39A, E44D, D123E, I135K, S163SC, I167IV, E169ED, K173E, I178L, G196E, T200A, R211K, L228H, A272P, K277R, E297A, V317A, Y342F, R358RK, T377M, K390R, A400T, K431T, V435I, L469I, T470TN, D488X | K32DE |
| >453| codons 1-488 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIEALLEICAELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSKNNETPGIRYQYNVLPQGWKGSPAIFQSCMTKVLDPFREQNPDLEI CQYMDDLYVGSDLEIEQHRAKIEELRQHLWKWGFYTPDNKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTAEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGQGQWTYQIFQEPFKNLKTGKYARMKGA HTNDVKQLTEAVQKIAMESIVIWGKTPKFRLPIQKETWETWWTEYWQATWIPEWEFVNTP PLVKLWYQLETEPIIGAETFYVDGAANRETKLGKAGYVTDRGRQKVVSINDTTNQKTELQ AIHLALQE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12A, D60E, Q61E, L63P, V77VI |
| >453| codons 1-99 PQITLWQRPLVAIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYE EIPIEICGHKAIGTVLIGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Hammer, SM | A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. | N Engl J Med, 1997 |