Isolate Data
Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
ACTG320_4281 | 4281 | U.S. | 1996 | HIV1 | B | Plasma | None |
Treatment History
Order | Regimen | Weeks |
1 | AZT | 221 |
RT Sequence
NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
M41L, T215Y | D67E | E6EG, V35T, V60I, S68G, D86DE, I135V, Q197E, T200A, Q207E, A272S, A288S, I293V, T338S, R356K, M357T, G359S, T377M, S379C, A400AT, T403TI, E404D, F416FY, A437V, K465R, L469I, L491S |
>4281| codons 1-492 PISPIGTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEKEGKISKIGPENPYNTPI FAIKKKEGTKWRKLVDFRELNKRTQEFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGEHRAKIEELREHLLRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGTKSLTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWSYQIYQEPFKNLKTGKYAKTRSA HTNDVKQLTEAVQKIAMECIVIWGKTPKFKLPIQKETWETWWIDYWQATWIPEWEYVNTP PLVKLWYQLEKEPIVGVETFYVDGAANRETKLGKAGYVTDRGRQRVVSITDTTNQKTELQ AIHLALQDSGSE |
Protease Sequence
PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
R41K, L63P, I72V, V77I, I93IL |
>4281| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QIPIEICGHKAVGTVLIGPTPVNIIGRNLLTQLGCTLNF |
References
Author | Title | Citation |
Hammer, SM | A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. | N Engl J Med, 1997 |