<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
ACTG320_4281 4281 U.S. 1996 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 221

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T215Y D67E     E6EG, V35T, V60I, S68G, D86DE, I135V, Q197E, T200A, Q207E, A272S, A288S, I293V, T338S, R356K, M357T, G359S, T377M, S379C, A400AT, T403TI, E404D, F416FY, A437V, K465R, L469I, L491S  
>4281| codons 1-492
PISPIGTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEKEGKISKIGPENPYNTPI
FAIKKKEGTKWRKLVDFRELNKRTQEFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGEHRAKIEELREHLLRWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGTKSLTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWSYQIYQEPFKNLKTGKYAKTRSA
HTNDVKQLTEAVQKIAMECIVIWGKTPKFKLPIQKETWETWWIDYWQATWIPEWEYVNTP
PLVKLWYQLEKEPIVGVETFYVDGAANRETKLGKAGYVTDRGRQRVVSITDTTNQKTELQ
AIHLALQDSGSE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    R41K, L63P, I72V, V77I, I93IL  
>4281| codons 1-99
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD
QIPIEICGHKAVGTVLIGPTPVNIIGRNLLTQLGCTLNF

References
Author Title Citation
Hammer, SM A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. N Engl J Med, 1997