<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
ACTG320_3968 3968 U.S. 1996 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 11
2 AZT+ DDC 179
3 AZT 4

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L210W, T215Y       K22KN, E28A, V35L, E44ED, R83K, K104N, V118VI, K122KE, S162SG, I178L, H208HY, R211RK, A272P, K277R, E297K, K311R, G333E, Q334H, R356K, K366R, T386I, A400T, V435I, D460N, Q480X  
>3968| codons 1-480
PISPIETVPVKLKPGMDGPKVNQWPLTAEKIKALLEICTELEKDGKISKIGPENPYNTPV
FAIKKKNSDKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKNSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQGSMTKILEPFRKQNPDLVI
YQYMDDLYVGSDLEIGQHRTKIEELRQYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTKEAE
LELAENREILREPVHGVYYDPSKDLIAEIQKQEHGQWTYQIYQEPFKNLKTGKYAKMRGA
HTNDVRQLTEAVQKIATESIVIWGKIPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIIGAETFYVDGAANRETKLGKAGYVTNRGRQKVVSLTDTTNQKTELH

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    A22X, L63P, K70R  
>3968| codons 22-99
TLLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYDQIPIEICGHRAIGTVLVGPTP
VNIIGRNLLTQIGCTLNF

References
Author Title Citation
Hammer, SM A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. N Engl J Med, 1997