<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
ACTG320_3711 3711 U.S. 1996 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 84
2 AZT+ DDI 6
3 None 18
4 AZT+ IDV+ 3TC 1

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    L19LI, E35D, N37NS, I62IV, L63P, I72IV, V77I, I93IL  
>3711| codons 1-99
PQITLWQRPLVTIKIGGQIKEALLDTGADDTVLEDMSLPGRWKPKMIGGIGGFIKVRQYD
QVPIEICGHKAVGTVLIGPTPVNIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        R83RK, K122KE, I135IT, S162CY, T165TI, K166N, T200A, Q207QH, R211RK, F214FL, A272AP, K277KR, L283LI, R284RK, T286TA, I293IV, I329L, M357T, V381I, Q394L, E399D, A400T, E449ED, L452LS, D460N  
>3711| codons 1-488
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMINILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRAKIEELRHHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIKGAKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAELQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA
HTNDVKQLTEAVQKIATESIIIWGKTPKFKLPILKETWDTWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRDTKSGKAGYVTNRGRQKVVSLTDTTNQKTELQ
AIHLALQD

References
Author Title Citation
Hammer, SM A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. N Engl J Med, 1997