Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ACTG320_361 | 361 | U.S. | 1996 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDC+ AZT | 67 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67NT, K70R, T215F | K219E | E6D, T39TP, T69N, K102Q, S162C, I202V, L210F, R211K, L228H, K277R, T286A, P294T, E297K, Y342F, M357I, R358K, A376V, K390R, A400T, T403TM, N447S, L452I, T470A, H483C |
| >361| codons 1-491 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICPEMEKEGKISKIGPENPYNTPV FAIKKKTSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKQKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKVEELRQHLFKWGFFTPDEKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTEVITLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIFQEPFKNLKTGKYARIKGA HTNDVKQLTEAVQKIVTESIVIWGKTPKFRLPIQKETWETWWMEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIVGAETFYVDGAASRETKIGKAGYVTDRGRQKVVSLADTTNQKTELQ AICLALQDSGL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| N37A, I62V, L63P, H69HY, V77VI |
| >361| codons 5-99 LWQRPLVTIKIGGQLKEALLDTGADDTVLEEMALPGRWKPKMIGGIGGFIKVRQYDQVPI EICGYKAIGTVLIGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Hammer, SM | A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. | N Engl J Med, 1997 |