Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ACTG320_354 | 354 | U.S. | 1996 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 273 |
| 2 | AZT+ DDI | 88 |
| 3 | AZT+ D4T | 54 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L33I | N37AS, L63P |
| >354| codons 8-99 RPLVTIKIGGQLKEALLDTGADDTVIEEMSLPGRWKPKMIGGIGGFIKVRQYDQIPIEIC GHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, T215Y | K219Q | A98S, D123E, D218E, E248D, I293V, I329V, A371AV, A376S, K390R, I393M, K395R, A400S, V435I, L452S, S468P, H483Y |
| >354| codons 1-485 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFYTPEQKHQKEPPFLWMGYELHPDKWT VQPIVLPDKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEVVQKISTESIVIWGKTPKFRLPMQRETWESWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIIGAETFYVDGAANRETKSGKAGYVTDRGRQKVVPLTDTTNQKTELQ AIYLA |
References
| Author | Title | Citation |
| Hammer, SM | A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. | N Engl J Med, 1997 |