Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ACTG320_353 | 353 | U.S. | 1996 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 138 |
| 2 | DDI | 177 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, V75T, T215F | K219Q | K20R, A98S, K102R, P176PS, D177G, G196E, K277KR, I293V, P294T, E297K, I326IMT, G359S, A371AV, A376S, T377S, A400T, E404ED, A446AS, K451R, D460N, H483HY | S156SL |
| >353| codons 1-492 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLTDFRELNKRTQDFWEVQLGIPHPSGLKRKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGLPAIFQSSMTKILEPFRKQNSGIVI YQYMDDLYVGSDLEIEQHRTKIEELRQHLLRWGFFTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTEVVTLTKEAE LELAENREILKEPVHGVYYDPSKDLTAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEVVQKISSESIVIWGKTPKFKLPIQKETWETWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKEPIVGAETFYVDGASNRETRLGKAGYVTNRGRQKVVSLTDTTNQKTELQ AIYLALQDSGLE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G16E, N37D, R41K, I62V, L63P, I72T, V77I, I93L |
| >353| codons 1-99 PQITLWQRPLVTIKIEGQLKEALLDTGADDTVLEEMDLPGKWKPKMIGGIGGFIKVRQYD QVPIEICGHKATGTVLIGPTPVNIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Hammer, SM | A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. | N Engl J Med, 1997 |