<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
ACTG320_3223 3223 U.S. 1996 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 193
2 AZT+ DDI 84
3 AZT+ DDC 24
4 None 2

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, T69D, K70R, L74LI, T215F K219Q K103KNRS   K20R, V35L, K104KN, V118I, K122E, D123E, T200A, Q207E, R211K, F214L, V245Q, I293V, R356RK, R358RK, E370ED, A371V, K390R, K395R, E399D, V435IT, S468P  
>3223| codons 1-490
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICTEMEKEGKISKIGPENPYNTPV
FAIKKKNSDRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKSNSVTVLDVGDAYFSIPL
DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRAKIEELREHLLKWGLFTPDQKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMKGA
HTNDVKQLTDVVQKIATESIVIWGKTPKFRLPIQRETWDAWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPITGAETFYVDGAANRETKLGKAGYVTDRGRQKVVPLTDTTNQKTELQ
AIHLALQDSG

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    E35D, N37S, R41K, K43R, R57K, I62V, L63P, A71T, V77I, V82I, I93L  
>3223| codons 13-99
IKIGGQLKEALLDTGADDTVLEDMSLPGKWRPKMIGGIGGFIKVKQYDQVPIEICGHKTI
GTVLIGPTPINIIGRNLLTQLGCTLNF

References
Author Title Citation
Hammer, SM A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. N Engl J Med, 1997