Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ACTG320_3223 | 3223 | U.S. | 1996 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 193 |
| 2 | AZT+ DDI | 84 |
| 3 | AZT+ DDC | 24 |
| 4 | None | 2 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, L74LI, T215F | K219Q | K103KNRS | K20R, V35L, K104KN, V118I, K122E, D123E, T200A, Q207E, R211K, F214L, V245Q, I293V, R356RK, R358RK, E370ED, A371V, K390R, K395R, E399D, V435IT, S468P |
| >3223| codons 1-490 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKSNSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELREHLLKWGLFTPDQKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMKGA HTNDVKQLTDVVQKIATESIVIWGKTPKFRLPIQRETWDAWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPITGAETFYVDGAANRETKLGKAGYVTDRGRQKVVPLTDTTNQKTELQ AIHLALQDSG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| E35D, N37S, R41K, K43R, R57K, I62V, L63P, A71T, V77I, V82I, I93L |
| >3223| codons 13-99 IKIGGQLKEALLDTGADDTVLEDMSLPGKWRPKMIGGIGGFIKVKQYDQVPIEICGHKTI GTVLIGPTPINIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Hammer, SM | A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. | N Engl J Med, 1997 |