Isolate Data
Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
ACTG320_273 | 273 | U.S. | 1996 | HIV1 | B | Plasma | None |
Treatment History
Order | Regimen | Weeks |
1 | AZT | 23 |
2 | AZT+ DDI | 7 |
RT Sequence
NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
D67N, K70R, T215Y | V118I, K122E, I135T, T165I, Q174L, I202V, Q207E, R211RG, F214L, V245T, A272P, I293V, E298EK, K311R, I329V, G333D, A360T, K390R, A400T, K431T, L452S, R463D, Q464K, K465R, V466F, S468P | G462E |
>273| codons 1-482 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMIKILEPFRKLNPDIVI YQYMDDLYVGSDLEIGQHRTKVEELREHLLGWGLYTPDKKHQKEPPFLWMGYELHPDKWT VQPITLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEKAE LELAENREILREPVHGVYYDPSKDLIAEVQKQDQGQWTYQIYQEPFKNLKTGKYARMRGT HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWETWWTEYWQATWIPEWEFVNTP PLVKLWYQLETEPIVGAETFYVDGAANRETKSGKAGYVTDREDKRFVPLTDTTNQKTELQ AI |
Protease Sequence
PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
E35D, M36I, R57K, Q61E, I62IV, L63P, A71T, I72V, V77I, I93L |
>273| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFIKVKQYD EVPIEICGHKTVGTVLIGPTPVNIIGRNLLTQLGCTLNF |
References
Author | Title | Citation |
Hammer, SM | A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. | N Engl J Med, 1997 |