Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ACTG320_2729 | 2729 | U.S. | 1996 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 226 |
| 2 | AZT+ DDC | 51 |
| 3 | AZT | 14 |
| 4 | AZT+ DDI | 31 |
| 5 | AZT+ DDI+ NVP | 135 |
| 6 | AZT+ DDI | 11 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, L210W, T215Y | K219Q | K103N, Y181C | P4H, T39A, E44D, V60I, K122E, I135T, I142V, S162A, G196E, I202V, E203K, Q207E, R211RK, H221Y, L228H, K277R, E291D, I293V, E297A, V317A, I329V, Q334L, M357T, A360V, A400T, K451R, D460N, V467I, T470A |
| >2729| codons 1-487 PISHIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPI FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIVI CQYMDDLYVGSDLEIEQHRTKVKELREHLWKWGFYTPDQKYQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTDVVPLTAEAE LELAENREILKEPVHGAYYDPSKDLIAEVQKQGLGQWTYQIYQEPFKNLKTGKYARTRGV HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIVGAETFYVDGAANRETRLGKAGYVTNRGRQKVISLADTTNQKTELQ AIHLALQ |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| N37D, I62IV, L63P, V77VI, I93L |
| >2729| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKAIGTVLIGPTPVNIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Hammer, SM | A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. | N Engl J Med, 1997 |