<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
ACTG320_2729 2729 U.S. 1996 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 226
2 AZT+ DDC 51
3 AZT 14
4 AZT+ DDI 31
5 AZT+ DDI+ NVP 135
6 AZT+ DDI 11

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, K70R, L210W, T215Y K219Q K103N, Y181C   P4H, T39A, E44D, V60I, K122E, I135T, I142V, S162A, G196E, I202V, E203K, Q207E, R211RK, H221Y, L228H, K277R, E291D, I293V, E297A, V317A, I329V, Q334L, M357T, A360V, A400T, K451R, D460N, V467I, T470A  
>2729| codons 1-487
PISHIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPI
FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIVI
CQYMDDLYVGSDLEIEQHRTKVKELREHLWKWGFYTPDQKYQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTDVVPLTAEAE
LELAENREILKEPVHGAYYDPSKDLIAEVQKQGLGQWTYQIYQEPFKNLKTGKYARTRGV
HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETRLGKAGYVTNRGRQKVISLADTTNQKTELQ
AIHLALQ

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    N37D, I62IV, L63P, V77VI, I93L  
>2729| codons 1-99
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD
QVPIEICGHKAIGTVLIGPTPVNIIGRNLLTQLGCTLNF

References
Author Title Citation
Hammer, SM A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. N Engl J Med, 1997